Introduction
Cradle develops AI models that design better-performing proteins. To train and validate these models, their team runs hundreds of protein expression, purification, and testing experiments each week. Performing these steps manually was time-consuming and limited throughput - automation was the key to scaling up.
The challenge? Cradle is not a traditional research lab. Their environment, goals, and setup required a fully customized automation platform, one that not only performed flawlessly but also looked exceptional.
The result is a bespoke, high-throughput protein purification system that combines robotics, modular hardware, and smart workflow software, all designed to fit Cradle’s unique requirements.
Tailored design for a unique environment
Every platform we build starts from the customer’s needs. For Cradle, this meant developing a completely custom-made solution:
- Designed for a non-lab environment, with special attention to safety, accessibility, and visual appeal.
- Built as a showpiece, positioned behind glass and visible from every angle. Clean, elegant, and inspiring.
- Developed to ensure all devices could still be used in standalone mode, offering full flexibility for testing and development.
Technical highlights
The platform automates the complete protein purification workflow, including plate handling, liquid transfers, and washing steps.
Key features include:
- PreciseFlex Robotic Arm with PlateCruiser module for smooth, reliable plate transfers.
- Turntables beneath the Spark plate reader and I.DOT dispenser for seamless switching between automated and manual operation.
- Modular instruments make it easier for maintenance without the need for recalibration.
- PlateButler® workflow software managing all scheduling and communication between devices.
- Custom-engineered integration of a Thermocycler Opentrons unit. Achieved despite its software being embedded in another system.
- Pixel instrument installed on a custom drawer with HEPA filtration, ensuring sample protection from external contaminants.
- Smart safety design: when a door opens, the system automatically slows down rather than performing a full stop, maintaining both safety and efficiency.
Results & impact
The completed platform transformed Cradle’s experimental capacity and workflow efficiency:
- Throughput doubled: more experiments completed in less time, without sacrificing quality.
- Manual work drastically reduced, freeing scientists to focus on data analysis and model development.
- Rapid workflow setup: new experimental protocols can be implemented and tested quickly.
- Consistent, high-quality results, generating reliable data for AI training.
- Improved user experience: intuitive operation, easier maintenance, and reduced downtime.
Why choose this solution
This solution is ideal for labs and companies that:
- Require high-throughput automation without compromising on flexibility or precision.
- Want fully integrated workflows that connect multiple instruments and devices seamlessly.
- Need custom solutions tailored to unique environments, experimental goals, or regulatory requirements.
- Value a platform that is both functional and visually impressive, serving as a centerpiece for demonstrations or client visits.
- Seek reliable long-term performance, with modular components that simplify maintenance and reduce downtime.
In short, this platform is not just automation, it is a complete solution designed to maximize efficiency, data quality, and user experience, while adapting to the unique needs of each customer.